Andy Burnham is to become the first PM to work from No10 North.
No10 North will be based in Heron House in Manchester City Centre.
Burnham is expected to work from No10 North each week so that decisions about the country's economic future will no longer exclusively be made in Westminster. Other ministers are also expected to work from the location.
The PM is to chair the first meeting of the revived National Economic Council at No10 North on Friday. This will bring together senior ministers and regional mayors to put devolution at the centre of the Government's mission to make Britain better.
Prime Minister Andy Burnham said: “For 40 years, power and resources have been sucked into the centre, and too many communities have felt forgotten, without the attention and investment they deserve.
“No 10 North will change that by putting more power into every postcode across the entire country.
“It will be the situation room for making Britain better - the place we use to get power out of Westminster, into the hands of people at a local level, so that they can turn things around.
“The days of Whitehall resisting devolution are over, for good.”
First Secretary of State Louise Haigh said: “Today marks a fundamental re-balancing of where power sits in our country. No10 North has been set up to drive economic growth in every postcode and put power in the hands of every community.
“Through this department, this Government will ensure that the places overlooked by Westminster for decades are given a real voice. No.10 North is open for business.”